Russian National Research Medical University Research Articles

[Erratum in "Point-of-Care Blood Glucose Testing: Post-Market Performance Assessment of the Accu-Chek Inform II Hospital-Use Glucose Meter" (DOI: 10.26442/00403660.2023.12.202522)].

In the article "Point-of-care blood glucose testing: post-market performance assessment of the Accu-Chek Inform II hospital-use glucose meter," published in the Terapevticheskii Arkhiv journal, Vol. 95, No.12, 2023 (DOI: 10.26442/00403660.2023.12.202522), errors were made: the term "measurements at the place of treatment" was changed, as well as the section "Conflict of interest." At the request of the authors' team, errors in the conflict of interest and the wording of the term have been corrected, and the section "Information about the authors" has been updated. The publisher replaced the original version of the published article with the corrected one; the information on the website was also corrected. Correct text of the section "Conflict of interest": Conflict of interest. All authors are not employees or consultants of Roche Diagnostics and have not received any compensation from Roche Diagnostics. Correct wording of the term in Russian: "измерения по месту лечения". Changes were made to the title of the article in Russian: "Измерения глюкозы по месту лечения: пострегистрационное испытание госпитального глюкометра Акку-Чек Информ II", the text of the abstract, keywords, citation, in the text of the article, and abbreviations. Information of the place of work has been updated: Center for Laboratory Diagnostics of the Russian Children Clinical Hospital, a Branch of the Pirogov Russian National Research Medical University. The publisher apologizes to readers and authors for the errors and is confident that the correction of errors will ensure the correct perception and interpretation of the results of the study described in the text.

To 110th anniversary of cardiac surgeon and researcher Igor N. Meshalkin

Igor N. Meshalkin (1913–1996) was Soviet cardiac surgeon, Dr. Sci. (Medicine). He was a graduate of the 2nd Moscow State Medical Institute (2nd MSMI, now the N.I. Pirogov Russian National Research Medical University). He was a participant in the Great Patriotic War. Igor N. Meshalkin began his professional career as a medical resident and an assistant of the clinic of faculty surgery in the 2nd MSMI since 1947; then as a medical resident of the Main Military Hospital of the Armed Forces of the USSR since 1951 and an assistant of the general surgery department of the pediatric faculty in the 2nd MSMI since 1954. In 1958–1963, he headed the Department of Acquired Heart Diseases in the Institute of Experimental Biology and Medicine (now the E.N. Meshalkin National Medical Research Center). In 1963–1977, Igor N. Meshalkin was the head of the department in the Central Clinical Hospital of the 4th Main Directorate of the USSR Ministry of Health. His research interests were focused on urgent abdominal surgery, thoracic surgery, mitral stenosis surgery. Igor N. Meshalkin was the author of 55 scientific works including two monographs. Received 8 November 2023. Accepted 14 November 2023. Funding: The study did not have sponsorship. Conflict of interest: The authors declare no conflict of interest. Contribution of the authors: The authors contributed equally to this article. Acknowledgment: The authors would like to thank Marina, daughter of Igor N. Meshalkin, for providing personal documents and photographs.

Vitamin D and Geriatric Assessment: A Cross-Sectional Study on the Cohort of Centenarians in the Central Region of Russian Federation

Background. The trend towards aging of  the population is  global, which makes the study of  etiology, prevention and treatment of  age-related disorders relevant. Increasing number of  studies highlights the influence of  25-hydroxyvitamin D deficiency on health state in older people, as well as its correlation with geriatric syndromes prevalence. However, at the moment it is not known whether these patterns persist in patients older than 90 due to the limited number of studies on this population.Aim. To assess the prevalence of vitamin D deficiency in a cohort of centenarians in the central region of Russian Federation and to study its relationship with the presence of geriatric syndromes.Materials and methods. The study was carried out by Russian Gerontology Research and Clinical Centre of  Pirogov Russian National Research Medical University and Center for Strategic Planning and Management of  Medical and Biological Health Risks. It was a cross-sectional study on the cohort of centenarians (90 years and older). Complex geriatric assessment was performed. Complex geriatric assessment included past medical history, geriatric scales and questionnaires (MMSE, SARC-F, MNA scores). Blood samples were taken to assess the 25-OH vitamin D levels using chemiluminescence method. The study is  reviewed by  the ethics committee (№ 30 24.12.2019). The statistical analysis was performed using Python version 3.9 and R version 4.1.3.Results. The study included 3,235 people aged 90 to 107 years. Median level of 25-hydroxyvitamin D was 9 ng/ml, 86.7% of participants were found to be 25(OH)D deficient, and in 8.3% insufficiency 25(OH)D was detected. Using the intergroup analysis, the association between 25-OH vitamin D levels and some geriatric syndromes, such as malnutrition, sarcopenia and cognitive impairment was observed. However, after adjusting to physical activity and nutrition statistically significant association was demonstrated only for cognitive impairment.Conclusion. The results obtained on the association between low levels of 25-OH vitamin D and cognitive impairment among centenarians confirm the importance of  vitamin D  deficiency prevention and might be  starting point for future studies.

5 P consortium “Children’s Medicine”

Medical consortia help solve current healthcare problems. Four scientific medical institutions (GBUZ of the Moscow region “Research Institute of Childhood of the Ministry of Health of the Moscow Region”, Scientific Research Clinical Institute of Pediatrics and Pediatric Surgery named after Academician Yu. E. Veltishchev Federal State Autonomous Educational Institution of Higher Education “Russian National Research Medical University named after N. I. Pirogov” of the Ministry of Health Russia, the Federal State Budgetary Institution “Medical Genetic Research Center named after Academician N. P. Bochkov”, the Federal Budgetary Institution “Moscow Research Institute of Epidemiology and Microbiology named after G. N. Gabrichevsky” of Rospotrebnadzor) and one higher educational institution (the Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation) united into the 5P “Children’s Medicine” consortium to solve pressing problems of children’s healthcare in accordance with the basic principles of personalized medicine. Organizing large congresses with international participation dedicated to the problems of children’s healthcare is an opportunity for doctors in the Russian Federation and other countries to share knowledge and best practices on saving a child’s life and treating diseases from an early age of the patient through direct communication. A systematic approach can be considered the most effective for solving problems in all areas, including children’s healthcare, and the 5 P “Children’s Medicine” congress helps doctors go beyond the boundaries of the familiar and familiar, learn new things, and get ideas for further professional growth.

E-Health Training of Medical Specialists in Russia

Purpose. The article discusses the improvement of e-Health training of medical specialists in Russia, and the challenges that doctors face when working with different health information systems. 
 Methodology. The study used both qualitative and quantitative data of the online survey conducted during the primary case study. Online survey targeted students of the Department of Medical Informatics and Cybernetics of N.I. Pirogov Russian National Research Medical University and doctors who were receiving initial training under the e-Health advanced training program. The survey aimed to determine systemic challenges and demand for training in various medical information systems. 
 Findings. Research data suggest that in order to bridge the digital gap, educational and training programs should include training versions of medical information systems used in Russian practical healthcare (electronic document flow system, EMIAS, Statistica, Sotsstrakh, Retsipient, etc.). It will enable doctors to enhance their theoretical and practical skills, abilities and knowledge, thus improving the quality of educational and work processes. Practicing health specialists who not only possess the theoretical knowledge, but also actively work in these areas (temporary disability examination, evaluation of medical care quality, work with citizens' appeals, compilation of numerous statistical reports, etc.) should be involved as mentors in the educational process. Simultaneous connection under the same login and password from multiple devices should be restricted to protect personal data and increase the security level of electronic document management systems in Russia.

Training of pediatricians in pediatric gastroenterology. To the 35th anniversary of the Department of Pediatrics with Infectious Diseases in Children of the Faculty of Additional Professional Education of the N. I. Pirogov’s Russian National Research Medical University

The article is devoted to the results of the training of pediatricians in pediatric gastroenterology based on the experience of the Department of Pediatrics with Infectious Diseases in Children (Head of the Department - prof. L. A. Kharitonova) N. I. Pirogov’s Russian National Research University of the Ministry of Health of Russia. The stages of development of the department are presented in detail. Since diseases of the digestive system have been and remain the main scientific direction of the work of the department staff, the issues of teaching gastroenterology and training both specialist doctors and pediatricians in this area influenced the goal-setting of the pedagogical process. Convincing evidence of the effectiveness of the rapid introduction of scientific and research achievements in practical health care. Fragments of the article highlight how, within the framework of training, joint medical work with organizations of health authorities in various regions of Russia, with which the department closely cooperates, they help spread knowledge. The prospects for the work of the department in the field of age-related non-infectious, infectious gastroenterology, biliary pathology and nutrition, further improvement of scientific and pedagogical activities, the quality of training of specialists in the field of pediatric gastroenterology are outlined. The article is dedicated to the 35th anniversary of the department.

Parallels between clinical and genetic characteristics in children with primary ciliary dyskinesia

Primary ciliary dyskinesia (PCD) is a rare genetic disorder that leads to chronic inflammatory damage to the airways and auditory organs. This article presents current information and a study aimed at investigating parallels between the course of PCD and clinical and genetic variant of the disease, which contributes to a timely diagnosis and enables personalized treatment approach.The aim of the study was to identify phenotypic characteristics and chronological patterns of PCD course depending on the genotype.Methods. The study was conducted at the Veltischev Research Clinical Institute of Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University (Pirogov Medical University), Ministry of Health of Russia. The study included children with PCD who underwent next generation sequencing (NGS) of the exome.Results. Significant differences were found in the course of PCD based on clinical and genetic characteristics. Children with defects in the genes encoding central pair proteins are characterized by an earlier onset of daily productive cough and recurrent respiratory infections. A similar pattern is typical for patients with defects in the genes encoding the cilia assembly proteins. The first episode of respiratory infection occurs later in patients with defects in the genes encoding dynein handle proteins. Patients who do not have defects in PCD-associated genes are characterized by a late onset of persistent difficulty in nasal breathing, productive cough and respiratory diseases.Conclusion. Identification of clinical and genetic variants of PCD allows prediction of chronological features of the course of the disease.

Experience in managing the process of continuing medical education of medical workers in public health and health care

Introduction. The problem of continuous professional development of medical specialists with higher and secondary medical education is especially relevant at the present stage, when medical knowledge, technologies, and drugs are being improved every day. 
 Purpose. Analysis of the forms of conducting cycles of continuous medical education in the field of health care management and public health at the Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation for the development of the most popular and perfect form of its implementation.
 Materials and methods. An analysis of the main directions of the mnagement of the process of continuous medical education of medical workers in general and in public health and health care in the Federal State Autonomous Educational Institution of Higher Education of the Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation. 
 Results. Since 1977 a continuous medical education was started in the USSR. A course for advanced training of doctors in social hygiene was opened at the Department of Social Hygiene and Health Organization of the 2nd Medical Institute. Within the framework of the specialty “Organization of Health Care and Public Health”, the department conducted cycles of professional retraining (PP-504 hours), advanced training: 144 hours (PC-144), 72 hours and 36 hours. Continuing medical education is aimed at obtaining the competencies necessary to perform a new type of professional activity. The plans for further improvement of continuing medical education by the department provide for the renewal of work programs, the creation of distance and new relevant cycles.
 Limitations of the study. An analysis of professional retraining cycles of students of various durations for the acquisition of new qualifications, qualitative expansion of the field of knowledge, skills and abilities in the period 2017–2022 was carried out. 
 Conclusion. The presented data indicate the expediency of managing advanced training within the framework of the specialty “Organization of Health Care and Public Health” using short cycles of advanced training of full-time and distant forms of training of students.

Обращение ректора РНИМУ имени Н.И. Пирогова академика С.А. Лукьянова

Message from the Rector of the Pirogov Russian National Research Medical University, Academician S.A. Lukyanov.

[Modern aspects of diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy in children].

Analysis of demographic, clinical, laboratory, electrophysiological and neuroimaging data and pathogenetic therapy of pediatric patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Patients (n=30) were observed in a separate structural unit of the Russian Children's Clinical Hospital of the Russian National Research Medical University named after. N.I. Pirogova Ministry of Health of the Russian Federation in the period from 2006 to 2023. The examination was carried out in accordance with the recommendations of the Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society on the Management of CIDP (2021). All patients received immunotherapy, including intravenous immunoglobulin (IVIG) (n=1), IVIG and glucocorticosteroids (GCS) (n=17, 56.7%), IVIG+GCS+plasmapheresis (n=12, 40.0%). Alternative therapy included cyclophosphamide (n=1), cyclophosphamide followed by mycophenolate mofetil (n=1), rituximab (n=2, 6.6%), azathioprine (n=3), mycophenolate mofetil (n=2, 6.6%). In all patients, there was a significant difference between scores on the MRCss and INCAT functional scales before and after treatment. At the moment, 11/30 (36.6%) patients are in clinical remission and are not receiving pathogenetic therapy. The median duration of remission is 48 months (30-84). The longest remission (84 months) was observed in a patient with the onset of CIDP at the age of 1 year 7 months. Early diagnosis of CIDP is important, since the disease is potentially curable; early administration of pathogenetic therapy provides a long-term favorable prognosis.

Research-to-practice conference as a component of improving knowledge and mastering professional competencies by medical students and young scientists

Aim. To evaluate the importance of certain aspects of research-to-practice conferences, organized by the Department of General Practice of Pirogov Russian National Research Medical University, as well as its contribution to preparing students for future professional activities within the outpatient healthcare and the impact of these events on the interest of participants and speakers for research work.Material and methods. An anonymous online survey included 37 participants in the discussed conferences regarding the respondents’ motivation to attend conferences, assessment of declared subject coverage, the practical applicability of the knowledge gained and other aspects.Results. The most important motivating factors for conference participation were interest in outpatient healthcare (52,4% for the conference "Internal diseases at the prehospital stage" and 87,5% for the conference "A multimorbid patient — continuity between hospital and clinic"), analysis of interesting cases (66,7% and 75%, respectively) and multidisciplinary focus of activities (47,6% and 68,8%). An important aspect was the coverage of current problems of practical healthcare. The most important results were considered by the majority of participants to be expanding their medical horizons (85,7% and 87,5%) and gaining new knowledge on the declared subject (90,5% and 75%). Almost half of the respondents (52,4% and 56,3%) improved their interest in scientific activities as a result of visiting the conferences.Conclusion. Conducting research-to-practice conferences for students, residents and postgraduates serves as a platform for increasing the knowledge and mastering professional competencies. The results of a survey of conference participants and speakers indicate the relevance of involving students in conferences and the numerous benefits they receive, which are discussed in detail in this article.

Georgii S. Bom — the founder of the Department of Traumatology, Orthopedics and Military Surgery of Pirogov Russian National Research Medical University

Georgii S. Bom was the founder of the Department of Traumatology, Orthopedics and Military Surgery of Pirogov Russian National Research Medical University. In 2023 the Department celebrated its 90th anniversary. Prof. S. Bom was also one of the founders of the Moscow orthopedic school and specialized in the treatment of pediatric orthopedic diseases, as well as bone and joint tuberculosis. He developed a number of original surgeries, in particular, an intervention for hallux valgus, which was called «Bom’s surgery». He offered a classification of all types of clubfoot, which is still used in orthopedics. Prof. G.S. Bom is the author of several monographs and a large number of scientific articles.

Point-of-care blood glucose testing: post-market performance assessment of the Accu-Chek Inform II hospital-use glucose meter

Background. A point-of-care glucose testing (POCT) is an essential component of care in patients with hyperglycemia and hypoglycemia in inpatient and outpatient medical facilities (MFs). In MFs conventional glucose meters designed for self-monitoring by patients with diabetes are commonly used for POCT. These home-use meters have two serious disadvantages: the first is large measurement bias and the second – they can’t be integrated into laboratory information systems, so measurement data have to be recorded into patient charts manually. Both factors may lead to medical errors. It is reasonable to use in the MFs specialized POCT glucose meters, as they are superior to conventional ones in accuracy and may be easily connected to laboratory information systems. With this in mind, physicians at the Russian Children’s Clinical Hospital – Branch of Pirogov Russian National Research Medical University – decided to substitute conventional meters with the Accu-Chek Inform II POCT meter, however, after preliminary performance assessment of the model.
 Aim. To test the Accu-Chek Inform II performance characteristics: accuracy, linearity, repeatability, mean absolute relative difference.
 Materials and methods. Performance of the Accu-Chek Inform II was tested by comparing the results of parallel CGL measurements with the meter and reference laboratory analyzer in capillary blood samples. Overall, 99 parallel CGL measurements were made in 45 samples. Accuracy was evaluated according to the ISO 15197-2013 and POCT12-A3 criteria.
 Results. The Accu-Chek Inform II meter met the requirements of ISO 15197-2013 and POCT12-A3 and demonstrated high linearity (correlation coefficient, r=1.0), good repeatability (mean coefficient of variation, CV=1.38%) and acceptable mean absolute relative difference (4.9%).
 Conclusion. The Accu-Chek Inform II POCT glucose meter may be efficiently and safely used in inpatient and outpatient MFs and particularly in pediatric clinics.

Клинические проявления и дифференциальная диагностика редкой формы наследственной дисплазии соединительной ткани - синдрома вялой кожи (сutis laxa)

Article is devoted to one of the rare forms of monogenic connective tissue disease, Cutis Laxa with an autosomal recessive type of inheritance (ARCL1C), the Urban-Rifkin-Davis syndrome. The bibliographical data on this disease and the medical records of a 6-year-old male pediatric patient who was observed at the Clinical Genetics Department of the Research and Clinical Institute of Pediatrics named after Academician Yuri Veltischev with the Pirogov Russian National Research Medical University (Moscow, Russia) are presented. In addition to skin lesions, the child had disorders of the cardiovascular, respiratory and urinary systems. The diagnosis was confirmed by the DNA diagnostics results: the two mutations in the compound heterozygous state were found in the LTBP4 gene: the variant rs397515430 p.1342C>T previously described in the scientific sources in exon 11 leading to a stop codon and premature termination of translation - p.Arg475Ter; the second variant, not previously described in the literature, was found in intron 4 - c.452-22A>C. A differential diagnosis with other phenotypically similar diseases was carried out. Further medical supervision of the patient should be carried out with the mandatory involvement of the pulmonologist, the cardiologist and the nephrologist.

НОВООБРАЗОВАНИЯ У ДЕТЕЙ С СИНДРОМОМ КОСТЕЛЛО: ОПЫТ РОССИЙСКОЙ ДЕТСКОЙ КЛИНИЧЕСКОЙ БОЛЬНИЦЫ

Costello Syndrome is an extremely rare genetic disorder caused by a mutation in the HRAS gene that encodes for a highly active protein that in its turn affects the cell growth and division. Patients have a unique phenotype and multiple developmental abnormalities that suggest the anomaly from the first days of life. The important feature of the disease is a predisposition to the development of neoplasms, both benign and malignant. This fact must obligatory be taken into consideration by physicians who are treating children with Costello Syndrome. Authors present the three clinical cases of children with Costello Syndrome coupled with neoplasms who underwent treatment at the Department of Surgical Treatment Methods of Oncology with the Russian Children's Clinical Hospital with the Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia (Moscow, Russia). The Authors’ experience in treating these patients, including a risk-adapted approach to therapy and early removal of detected formations, can be considered successful as yet. The descriptions of these clinical cases are of scientific and practical interest not only for pediatric oncologists but also for pediatricians, neurologists, cardiologists and other specialists due to the rarity of Costello Syndrome as they contribute to the formation of oncological vigilance.

Centennial experience of the work of the Department of Public Health and Healthсare named after Academician Yu.P. Lisitsyn

Public health and healthcare is an educational and scientific discipline that studies the state of health of the population depending on the environment, lifestyle, and organization of medical care and develops medical and social measures for disease prevention and health improvement of citizens. The department, which solves educational, pedagogical, and scientific problems of social hygiene, was organized in 1924 at the second Moscow State University (Department of Public Health and Public Health named after Academician Y.P. Lisitsyn at the N.I. Pirogov Russian National Research Medical University). The social and hygienic research carried out at the department made it possible to develop and describe the basic principles of Soviet healthcare. In 100 years, 200 dissertation studies have been conducted at the department.
 The Department has always been a model in all areas of activity thanks to its leaders — famous scientists, highly erudite teachers, leading organizers of health care and well-known public figures: Z.P. Solovyov, G.A. Batkis, G.B. Getsov, O.V. Grinina, Yu.P. Lisitsyn.

Academician Viktor Sergeyevich Savelyev (1928–2013) (on the 95th anniversary of his birth)

Outstanding surgeon, scientist, teacher and organizer of healthcare, founder of a large surgical school, Hero of Socialist Labor (1988), academician of the USSR Academy of Medical Sciences (1974), RAMS (1991) and RAS (1997), laureate of the USSR State Prize (1975), the State Prize of the Russian Federation (1992), Demidov Prize (2002) and the A. N. Bakulev Prize (2002), Professor Viktor Sergeevich Savelyev was born on February 24, 1928 in the village of Pakhotny Ugol of the Bondarsky district of the Tambov region in the family of Sergei Dmitrievich Savelyev, a wood sawmill worker, and Olga Kuzminichna, a housewife. In 1945, Viktor Sergeevich entered the 2nd Moscow Medical Institute (now the Pirogov Russian National Research Medical University). After graduating in 1951, he studied in residency at the Department of Faculty Surgery, which was headed by the academician A. N. Bakulev, and was stayed at the department as an assistant. After defending his PhD thesis in 1955, he was appointed a teacher. In 1959, V. S. Savelyev successfully defended his doctoral dissertation, in 1961, he passed the academic title of Professor, in 1967, he was elected the head of the Department of Faculty Surgery. Viktor Sergeevich fully became the successor of A. N. Bakuleva and made the very great contribution to the development of domestic cardiac surgery. The works of V. S. Savelyev played a huge role in the formation and rapid development of vascular surgery. The clinic he headed has accumulated the world’s largest experience in the treatment of acute thrombosis and embolism of the main arteries. Viktor Sergeevich is rightfully one of the founders of modern Russian phlebology. He also made a significant contribution to the development of surgery of the stomach, intestines, bile ducts and pancreas. He was one of the first in the country to use organ-preserving operations on the stomach for complicated duodenal ulcer. Many of Viktor Sergeevich’s works were devoted to various aspects of postoperative management of patients, infusion therapy and parenteral nutrition, pathogenesis, diagnosis and treatment of sepsis. V. S. Savelyev and his students made a significant contribution to the development of abdominal endoscopy. V. S. Savelyev was a major organizer of domestic healthcare, for 34 years he held the post of the chief surgeon of the Ministry of Health of Russia. He was the Chairman of the Scientific Society of Surgeons of Russia (ROH), founder and president of the Russian Association of Phlebologists, editor-in-chief of journals «Thoracic and Cardiovascular Surgery» and «Phlebolymphology». Under his leadership and with his participation as the scientific consultant, 70 doctoral and 180 candidate dissertations were defended. He was the author and co-author of more than 500 scientific papers, including 24 monographs and manuals. The academician Viktor Sergeevich Savelyev died on December 25, 2013 and was buried in Moscow at the Troyekurovo Cemetery.

Features of treatment of haemorrhoids in overweight patients

Hemorrhoidal disease is one of the most common proctological diseases in the population, covering, according to a number of authors, from 4 to 86% of the population over the age of 40 years. In addition, the problem of metabolic syndrome and accompanying obesity have become a real disease of the century in developed countries. This condition predisposes to a large number of diseases, including hemorrhoidal disease. From these positions, it is advisable to highlight the possibilities of treating not only hemorrhoids themselves, but also combating metabolic syndrome in this category of patients. The article describes modern data on the therapeutic effect of bioflavonoids, in particular hesperidin, and the mechanisms of their therapeutic action in acute and chronic hemorrhoids. The possibilities of using topical therapy for hemorrhoids are also highlighted, attention is paid to suppositories based on sodium alginate, thanks to which the drug has a hemostatic, anti-inflammatory and reparative effect, alleviating local symptoms of hemorrhoids and anal fissure. Data are provided on the therapeutic effect of the combination of hesperidin + diosmin in relation to the symptoms of hemorrhoids in patients with excess body weight and to metabolic syndrome are presented, as well as the experience of clinical observation in the hospital of the Faculty of Surgery No. 2 L/F of the N.I. Russian National Research Medical University is presented. Pirogov in the treatment of 1 300 comorbid patients with acute hemorrhoids and exacerbation of chronic hemorrhoids, followed by surgical treatment. The potential benefits of drugs with a standardized content of hesperidin (Venarus®) in relation to the treatment of hemorrhoids in patients with excess body weight and metabolic syndrome, comparison with other drugs from the group of bioflavonoids, are described.

Chronicles of A.I. Pospelov Moscow Society of Dermatovenerologists and Cosmetologists (MSDC was founded on October 4, 1891) 
 Bulletin of the MSDC meeting N 1153

On June 20, 2023, the 1153rd meeting of the Moscow Society of Dermatovenerologists and Cosmetologists named after A.I. Pospelov took place.
 The meeting was held in a "face-to-face" format. There were 86 participants in total. Applications for membership in the Moscow Society of Dermatovenerologists and Cosmetologists named after A.I. Pospelov were not submitted. Elections of delegates to the XXIII Congress of Dermatovenerologists and Cosmetologists of Russia (Corresponding member of the Russian Academy of Sciences, Professor O.Y. Olisova, Professor E.S. Snarskaya, Professor O.B. Tamrazova, Associate Professor A.B. Yakovlev, assistant I.S. Maksimov, doctor V.V. Savenkov) and nomination of candidates for the position of the President of the All-Russian Public Organisation "Russian Society of Dermatovenerologists and Cosmetologists" were held (Academician of the Russian Academy of Sciences A.A. Kubanov).
 Two reports are presented in the clinical part of the meeting: (1) paraneoplastic bullous dermatoses (Sechenov University); (2) Otto–Moncorps keratosis (Sechenov University).
 Reports were made in the scientific part of the meeting: (1) mycobacterial infection combined with skin mycoses in patients with HIV infection: diagnostic issues (Sechenov University, Pirogov Russian National Research Medical University); (2) under the "mask" of a scar (Sechenov University).

In memory of Alexander Markusovich Bronshtein

On August 11, 2023, at the age of 79 years, Alexander Markusovich Bronstein, Doctor of Medical Sciences, Professor of the Department of Infectious Diseases and Epidemiology of the Faculty of Medicine of the Russian National Research Medical University named after N.I. Pirogov, who worked on the editorial board of our magazine for more than a quarter of a century.